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  • Title: Cyclo (His-Pro), a metabolite of thyrotropin-releasing hormone: specific binding to rat liver membranes.
    Author: Mori M, Yamada M, Yamaguchi M, Suzuki M, Ohshima K, Kobayashi I, Kobayashi S.
    Journal: Biochem Biophys Res Commun; 1986 Jan 14; 134(1):443-51. PubMed ID: 3080990.
    Abstract:
    [3H]cyclo(His-Pro) bound with high affinity (59 nM) to a single class of sites in rat liver plasma membranes, without significant tracer degradation during equilibration for 60 min at 0 degrees C. Binding was specific and saturable (3.9 pmol/mg protein), and were increased by the addition of K+, Mg++ and Na+ at optimal concentrations, but not of Ca++ at all concentrations tested. In vivo administration of cyclo(His-Pro), but not thyrotropin-releasing hormone, to rats caused the downregulation of cyclo(His-Pro)-binding sites with decreases in specific binding numbers but did not change binding affinity.
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