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  • Title: Cytotoxic triterpenoid saponins from the root of Anemone tomentosa (Maxim.) Pei.
    Author: Zhang Y, Niu X, Jia Y, Lv C, Wang J, Jia L, Lu J.
    Journal: Nat Prod Res; 2020 Dec; 34(24):3462-3469. PubMed ID: 30810364.
    Abstract:
    Two new triterpenoid saponins, tomentoside T1 (1) and tomentoside T2 (2), together with eleven known compounds (3-13) were obtained from ethyl acetate extracts of Anemone tomentosa (Maxim.) Pei by bioactivity-guided isolation. Their structures were elucidated by chemical and spectral analysis, including 1D, 2D NMR data and HRESIMS. The cytotoxic activity of all isolated saponins was evaluated on MDA-MB-231 and PC-3 cell lines. Compounds 5 and 7 showed significant cytotoxicity against with MDA-MB-231 cell and PC-3 cell with IC50 values of 3.73-4.21 μM and 3.53-5.37 μM, respectively.
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