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  • Title: [Role of the endothelium in the development of the contractile reactions of vascular smooth muscle during decreased oxygenation].
    Author: Baziliuk OV, Bershteĭn SA, Solov'ev AI.
    Journal: Biull Eksp Biol Med; 1986 Feb; 101(2):139-41. PubMed ID: 3081058.
    Abstract:
    Noradrenaline-preactivated vascular smooth muscles (VSM) of the rat thoracic aorta showed two-phase reactions in response to decreased oxygenation: significant relaxation was preceded by transient constriction. When the endothelium was removed only VSM relaxation phase was retained, with no constriction observed. The data obtained suggest an endothelium-dependent nature of VSM constriction reaction to hypoxia, in contrast to endothelium-independent VSM relaxation. Intracellular calcium is also assumed to play an essential role in the formation of endothelium-dependent constriction VSM reaction to hypoxia.
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