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  • Title: TGF-β1 polymorphism in American tegumentary leishmaniasis in a Southern Brazilian population.
    Author: Shehadeh FVB, Santos RRD, Silva LADD, Silva Júnior WVD, Ribas-Silva R, Ribas AD, Silveira TGV, Borelli SD, Aristides SMA.
    Journal: Rev Soc Bras Med Trop; 2019 Feb 21; 52():e20170415. PubMed ID: 30810648.
    Abstract:
    INTRODUCTION: Genetic polymorphisms define the cytokine production leading to susceptibility or resistance to diseases. We studied the cytokine polymorphism in the development of tegumentary leishmaniasis (TL). METHODS: Genotyping of TNF-α, TGF-β1, IFN-γ, IL-6, and IL-10 were performed by polymerase chain reaction assay. RESULTS: G and C alleles of TGF- β1 (codon 25) were the most common in controls and patients, respectively. G/G was the most frequent genotype in controls, and G/C and C/C in patients. CONCLUSIONS: G/G genotype of codon 25 in TGF-β1 appeared to confer resistance, and G/C and C/C genotypes, susceptibility to TL in this population.
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