These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Predictive value of neutrophil-to-lymphocyte ratio in 30-day mortality of patients with acute paraquat poisoning].
    Author: Liang H, Gao Y, Liu Y, Gu SS, Cai N, Jiang M, Wang J, He F.
    Journal: Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi; 2018 Dec 20; 36(12):911-914. PubMed ID: 30812077.
    Abstract:
    Objective: To investigate the predictive value of neutrophil-to-lymphocyte Ratio (NLR) in 30-day mortality of patients with acute paraquat poisoning. Methods: We respectively reviewed the clinical parameters of 115 patients with acute paraquat poisoning. They were divided into survival (n=64) and non-survival (n=51) groups based on their 30-day outcome. Multivariate logistic regression was performed to identify risk factors of 30-day mortality. Receiver operating curve (ROC) test was applied to analysis to the predictive value of NLR in 30-day mortality ofacute paraquat poisoning patients. The correlations between NLR and severity index of paraquat poisoning (SIPP) were analyzed using Spearman's rank correlation coefficient. Results: Of the 115patients included in the study, 54 (46.96%) patients were males and 61 (53.04%) were females with a mean age of 38.96±13.58 years. The total mortality in 30-day was 44.35% (51/115) . The NLR at admission was an independently risk factor of 30-day mortality of patients with acute paraquat poisoning (OR 1.477, 95%CI 1.035-2.107, P<0.05) . The NLR to predict the death of the area under the ROC curve was 0.894 (95%CI: 0.8212-0.9663, P<0.01) ; the optimal cutoff threshold was 11.71; the sensitivity was 71.79% and the specificity was 94.29%; the positive predictive value was 93.33%and negative predictive value of 75.00%. Meanwhile, the positive likelihood ratio was 12.57 and the negative likelihood ratio was 0.30. The NLR was significantly associated with SIPP (Spearman rho 0.525; P<0.01) and it was significantly higher in patients with SIPP of ten or higher than in those with an SIPP less than 10 (15.02±12.40 vs. 6.19±2.54, P<0.05) . Conclusion: The increased NLR at admission was an independently risk factor of 30-day mortality of patients with acute paraquat poisoning and it was significantly correlated with SIPP score. Therefore, NLR was useful for predicting prognosis of patients with acute paraquat poisoning. 目的： 评估血中性粒细胞/淋巴细胞比率（Neutrophil-to-Lymphocyte Ratio，NLR）对急性百草枯中毒患者30 d死亡风险的预测价值。 方法： 回顾性分析收住南京大学医学院附属鼓楼医院急诊科的115例急性百草枯中毒患者临床资料，以中毒30 d后的临床转归情况分为存活组（64例）和死亡组（51例）。单因素及多因素logistic回归分析临床资料确定中毒患者死亡的高危因素。利用受试者工作特征曲线（receiver operating characteristic curve，ROC）评估NLR对中毒患者30 d死亡风险的预测价值。Spearman分析探讨NLR与百草枯中毒严重程度指数（severity index of paraquat poisoning，SIPP）之间的相关性。 结果： 急性百草枯中毒患者平均年龄（38.9±13.6）岁，男性54例，女性61例，总体病死率44.35%（51/115）。多因素Logistic回归分析显示，NLR是中毒患者死亡的危险因素（OR:1.477，95%CI: 1.035~2.107，P<0.05）。NLR预测效能的ROC曲线下面积为0.894（95%CI:0.821 2~0.966 3，P<0.01），最佳截断值为11.71（敏感度71.79%、特异度94.29%；阳性预测值93.33%、阴性预测值75.00%；阳性似然比12.57、阴性似然比0.30）。NLR与SIPP呈中等强度正相关（r=0.525, P<0.01），且SIPP≥10组患者NLR值（15.02±12.40）较SIPP<10组（6.19±2.54）均明显升高，差异有统计学意义（P<0.05）。 结论： NLR值增高是急性百草枯中毒患者死亡的高危因素，其与SIPP具有良好的相关性，对中毒患者的30 d死亡风险具有良好的预测价值。.
    [Abstract] [Full Text] [Related] [New Search]