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  • Title: Inhibition of platelet secretion of ATP by phalloidin.
    Author: Hashimoto K, Kawarabayashi K, Hashimoto K, Tatsumi N.
    Journal: Cell Biol Int Rep; 1986 Jan; 10(1):41-7. PubMed ID: 3081266.
    Abstract:
    The involvement of actin in the secretion of ATP by platelets was studied using two stimulants, ADP and A23187, and two actin-mediating reagents, cytochalasin B and phalloidin. The degree of actin polymerization was determined using DNase I. Preincubation of platelets with cytochalasin B suppressed the polymerization of actin and ATP secretion induced by stimulants. In the absence of the stimulant, phalloidin-treated platelets exhibited time-dependent actin polymerization and the maximum level was reached at 5 min. No secretion of ATP was observed. The polymerization was enhanced by phalloidin when the platelets were preincubated for 3 to 5 min with the stimulants, but little ATP was secreted. After a 30-min preincubation, the amount of polymerized actin was lower than that after a 5-min incubation, and no ATP was secreted.
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