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  • Title: [Effect of electrostimulation of the hypothalamus on the immunological reactivity of rats with 7,12-dimethylbenz[a]anthracene-induced tumors].
    Author: Vinnitskiĭ VB, Shevchenko IN, Isaeva EG, Lapteva NA.
    Journal: Eksp Onkol; 1986; 8(1):51-4. PubMed ID: 3081322.
    Abstract:
    Experiments on Wistar male rats established that electrostimulation of the area of the posterior hypothalamic nuclei 2.5 months after administration of 7,12-dimethylbenz(a)anthracene into the femur muscle restrained to a considerable extent the inhibitory effect of the carcinogen on the immune reactivity. The reactivity was estimated by the amount of antibody-forming and rosette-forming cells in the spleen, thymus, lymph nodes and by the activity of DNA synthesis in the cells of these organs. The effect of hypothalamus electrostimulation may be a determinant in the mechanism of the inhibitory action of chemical carcinogenesis.
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