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  • Title: [Monomycin distribution in the tissues of animals of various ages].
    Author: Gavrilov EM, Zhaugasheva SK, Shchepetkina LV.
    Journal: Farmakol Toksikol; 1986; 49(1):69-71. PubMed ID: 3081365.
    Abstract:
    The distribution of monomycin (15 mg/kg intramuscularly) in the blood serum and organs of mature, old and young rats was studied in the agar diffusion test. Bact. pumelis was used as test microorganism. The good absorption of this antibiotic into blood was revealed and its accumulation in high concentrations in the kidneys of animals of all ages, that conditions to a certain degree the nephrotoxicity of the preparation. Its accumulation in the organs and release from them is quicker in young rats than in mature and old ones. According to monomycin concentration, the organs were distributed in the following descending order: kidneys-liver-lungs-spleen.
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