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  • Title: Corneoscleral xanthogranuloma treated with chemotherapy: The room for nonsurgical management.
    Author: Mustafa OM, Daoud YJ.
    Journal: Eur J Ophthalmol; 2020 Mar; 30(2):NP23-NP26. PubMed ID: 30813780.
    Abstract:
    PURPOSE: To describe a clinical case of corneoscleral xanthogranuloma, a rare manifestation of juvenile xanthogranuloma, and xanthoma disseminatum, which responded well to chemotherapy. METHODS: Interventional case report and literature search. RESULTS: A 9-year-old female patient with a disseminated disease showed complete regression of her corneoscleral xanthogranuloma with methotrexate and azathioprine therapy. CONCLUSION: Since they are potentially blinding, corneoscleral xanthogranulomas are commonly surgically excised. While surgical resection has been widely advocated in the literature, immunosuppressive therapy alone may be a pertinent management line of corneoscleral xanthogranuloma, especially with systemic involvement.
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