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  • Title: Role of Red Blood Cell Distribution Width in Predicting Cardiac Syndrome X in Women.
    Author: Zhao K, Li Y.
    Journal: Ann Clin Lab Sci; 2019 Jan; 49(1):89-93. PubMed ID: 30814082.
    Abstract:
    OBJECTIVE: To investigate whether the increased red blood cell distribution width (RDW) is a biomarker for predicting the presence of cardiac syndrome X (CSX) in women. METHODS: 110 CSX women patients and 98 normal controls were prospectively enrolled in this study. The CSX group consisted of patients with anginal chest pain, ischemia on noninvasive stress test and a normal coronary angiography. The control group was selected from the patients with anginal symptoms but those who had a normal stress test and a normal coronary angiography. Blood samples were drawn from all women patients for measuring RDW and C-reactive protein (CRP). Then the baseline data were compared between CSX patients and normal controls. RESULTS: Baseline characteristics of the two groups were similar. The serum RDW levels and CRP levels were significantly higher in the CSX group than those in the normal control group (P<0.01). Patients with CSX had higher diabetes mellitus (DM) and menopausal rates (P<0.05). In a multivariate analysis, RDW levels, CRP levels and DM were associated independently with CSX in women. CONCLUSIONS: Serum RDW level may independently predict CSX in women, which indicates that a chronic inflammatory response might be involved in the pathogenesis of CSX.
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