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  • Title: Deduced primary structure of the alpha subunit of the GTP-binding stimulatory protein of adenylate cyclase.
    Author: Robishaw JD, Russell DW, Harris BA, Smigel MD, Gilman AG.
    Journal: Proc Natl Acad Sci U S A; 1986 Mar; 83(5):1251-5. PubMed ID: 3081893.
    Abstract:
    A bovine adrenal cDNA clone encoding the entire alpha subunit of the GTP-binding regulatory protein that stimulates adenylate cyclase (Gs) was isolated and sequenced. This cDNA directed the synthesis of the larger, 52-kDa form of the polypeptide in COS cells, even though the clone appeared to encode a 46-kDa protein. Comparison of the deduced amino acid sequence of Gs alpha with the alpha subunit of another G protein, transducin, revealed striking homologies.
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