These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: The acid-base balance during the time course of endotoxin fever and sodium salicylate antipyresis in the rabbit.
    Author: Gagało IT, Hać EE.
    Journal: Pharmacol Res Commun; 1986 Jan; 18(1):17-30. PubMed ID: 3081916.
    Abstract:
    Blood acid-base balance in sodium salicylate antipyresis was investigated in adult rabbits at ambient temperature of 21.5 +/- 0.5 degrees C. The experimental fever elicited by iv injection of lipopolysaccharide Escherichia coli 1 microgram/kg/ was accompanied by a slight metabolic acidosis. A decrease in pH by 0.09 and HCO3- by 4.8 mEq/1 was noticed during the rising phase of pyrogen fever. There were no concomitant changes in blood PCO2 during that period of time. Although the concentrations of HCO3- were decreasing till the end of the experiment, the parallel falls in PCO2 led to a partial compensation of the noticed acidosis. Pretreatment with 200 mg/kg of sodium salicylate /an hour's iv infusion/reduced the febrile response by 42% and completely reversed the postpyrogen changes in pH and HCO3-. The falls in PCO2 during antipyresis, however, were similar to those observed in febrile rabbits. Possible mechanisms by which sodium salicylate could affect the pyrogen-induced disturbances of acid-base balance are being considered.
    [Abstract] [Full Text] [Related] [New Search]