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  • Title: Corticotropin-releasing factor potentiates acoustic startle in rats: blockade by chlordiazepoxide.
    Author: Swerdlow NR, Geyer MA, Vale WW, Koob GF.
    Journal: Psychopharmacology (Berl); 1986; 88(2):147-52. PubMed ID: 3081925.
    Abstract:
    A series of experiments was performed to investigate the effects of corticotropin-releasing factor (CRF) on the amplitude of the acoustic startle response (ASR) in rats. Intracerebroventricular (ICV) administration of 1 microgram rat CRF significantly potentiated acoustic startle amplitude; these effects were reversed in a dose-dependent manner by pretreatment with the benzodiazepine chlordiazepoxide (CDP). Doses of CDP that antagonized CRF-potentiated ASR did not lower startle baseline or antagonize amphetamine- or strychnine-potentiated ASR. These results suggest that CRF has "anxiogenic" properties and may serve as a neuroendocrine modulator of stress-enhanced behaviors.
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