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  • Title: Asymmetric Synthesis of α-Alkylidene-β-Lactams through Copper Catalysis with a Prolinol-Phosphine Chiral Ligand.
    Author: Imai K, Takayama Y, Murayama H, Ohmiya H, Shimizu Y, Sawamura M.
    Journal: Org Lett; 2019 Mar 15; 21(6):1717-1721. PubMed ID: 30821461.
    Abstract:
    A copper/prolinol-phosphine chiral catalyst enabled the one-step synthesis of chiral α-alkylidene-β-lactams. Optimization of the chiral ligand for steric and electronic properties realized the highly enantioselective coupling of nitrones and propargyl alcohol derived alkynes. The resulting chiral α-alkylidene-β-lactams served as a platform for various β-lactams via well-established transformations of α,β-unsaturated carbonyl compounds.
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