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  • Title: Oxygen consumption in fetal lambs after maternal administration of sodium pentobarbital.
    Author: Rurak DW, Taylor SM.
    Journal: Am J Obstet Gynecol; 1986 Mar; 154(3):674-8. PubMed ID: 3082210.
    Abstract:
    To determine whether anesthesia lowers fetal oxygen consumption, sodium pentobarbital (10 mg/kg) was given intravenously to seven chronically instrumented pregnant ewes (123 to 144 days' gestation). Oxygen consumption fell by 23% in association with a rise in fetal vascular PO2. Fetal breathing movements were abolished for 50.5 minutes, while the number of fetal heart rate accelerations fell by 80% in the first 30 minutes after pentobarbital injection. It is concluded that anesthesia reduces fetal oxygen consumption, probably by abolishing skeletal muscle activity, and perhaps also by reducing cerebral metabolic rate.
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