These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Prostaglandin synthetase activity in the different layers of the kidneys of young rats exposed to polyene antibiotics].
    Author: Efendiev AM, Pomoĭnetskiĭ VD, Kubatiev AA.
    Journal: Biull Eksp Biol Med; 1986 Mar; 101(3):302-4. PubMed ID: 3082383.
    Abstract:
    Prostaglandin (PG)-synthestase activity was studied in the cortical, medullary and papillary kidney layers in young rats subjected to prolonged administration of polyene antibiotics (amphotericin B, levorin and nystatin). This activity was markedly increased during the first few hours after the administration of amphotericin B. At later terms a pronounced decline in the enzyme activity was observed. The changes were most prominent in the medullary and papillary layers. The other two antibiotics were less potent. The experimental results have shown that amphotericin B had maximal effect on renal PG-synthetase activity, while the sodium salt of nystatin was least effective.
    [Abstract] [Full Text] [Related] [New Search]