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  • Title: [Hyperthyroidism in the thyroid hormone treatment of iodine deficiency goiter].
    Author: Emrich D, Klaushenke G.
    Journal: Dtsch Med Wochenschr; 1986 Apr 11; 111(15):577-81. PubMed ID: 3082613.
    Abstract:
    Standardized assessment of 1973 patients with iodine-deficient goitre, treated on average with 100 micrograms thyroxin, revealed clinical signs of thyroid hyperfunction in 2.4%. But an increased hormone concentration alone was not sufficient for the diagnosis. Probable cause of hyperfunction was autonomy of the goitre, as indicated by a negative TRH test before treatment had begun. It was calculated that in this case the risk of hyperthyroidism from thyroid hormone administration was 10%, but only 0.7% in patients with a primarily positive TRH test. Hyperthyroid symptoms disappeared and hormone concentration became normal in 60% of patients after thyroid-hormone administration had been stopped. It is concluded that patients with primarily negative TRH test must be carefully monitored while receiving thyroid-hormone treatment.
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