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  • Title: FR-900452, a specific antagonist of platelet activating factor (PAF) produced by Streptomyces phaeofaciens. I. Taxonomy, fermentation, isolation, and physico-chemical and biological characteristics.
    Author: Okamoto M, Yoshida K, Nishikawa M, Ando T, Iwami M, Kohsaka M, Aoki H.
    Journal: J Antibiot (Tokyo); 1986 Feb; 39(2):198-204. PubMed ID: 3082838.
    Abstract:
    A PAF antagonist, designated as FR-900452, was isolated from fermentation products of Streptomyces phaeofaciens and the molecular formula was determined as C22H25N3O3S. The compound inhibited PAF-induced rabbit platelet aggregation with an IC50 of 3.7 X 10(-7)M, but was much less active against collagen-, arachidonic acid- or ADP-induced aggregation (IC50; 6.4 X 10(-5), greater than 10(-4) or greater than 10(-4)M, respectively).
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