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  • Title: Effect of the beta-2 adrenergic agonist fenoterol on the release of leukotrienes and prostaglandin D2 from human lung parenchyma.
    Author: Viganò T, Sautebin L, Crivellari MT, Galli G, Mezzetti M, Folco GC.
    Journal: Wien Klin Wochenschr; 1986 Feb 21; 98(4):120-22. PubMed ID: 3085356.
    Abstract:
    Ca++-ionophore and antigen challenge of human lung fragments caused a massive release of leukotrienes, whose relative proportions varied considerably and were dependent on the experimental conditions. A broncho-selective beta 2-adrenoceptor agonist fenoterol was able to prevent the antigen-induced leukotriene release completely, whereas the Ca++-ionophore induced leukotriene release was only moderately inhibited. The HPLC data were confirmed by SRS-A bioassay.
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