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  • Title: Autonomous ovarian hyperfunction followed by gonadotrophin-dependent puberty in McCune-Albright syndrome.
    Author: Kaufman FR, Costin G, Reid BS.
    Journal: Clin Endocrinol (Oxf); 1986 Mar; 24(3):239-42. PubMed ID: 3085997.
    Abstract:
    A 5-year-old girl with the McCune-Albright syndrome presented with precocious puberty secondary to autonomously functioning ovarian cysts, followed by true central puberty. Progression from gonadotrophin-independent to gonadotrophin-dependent precocious puberty may occur from elevated sex steroid levels leading to the early maturation of the hypothalamic-pituitary axis.
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