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  • Title: An inhibitor to factor VIII:C in a patient with possible combined haemophilia A and von Willebrand's disease.
    Author: Taylor LD, Dean FL, Tiedemann K, Ekert H.
    Journal: Thromb Haemost; 1986 Apr 30; 55(2):158-61. PubMed ID: 3087000.
    Abstract:
    A factor VIII inhibitor has been found in a patient with an unusual combination of factor VIII-related properties. The inhibitor is directed specifically against the clotting activity (VIII:C) of the factor VIII complex. It behaves in a similar fashion to high responding inhibitors of factor VIII seen in haemophilia A patients and it was characterised as an immunoglobulin of the IgG class. Laboratory results from the patient and his family show considerable variation of factor VIII-related properties between various individuals. Overall, the data suggests the co-existence of haemophilia A and von Willebrand's disease in the family and the presence of both diseases in the patient.
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