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  • Title: [Immunoprophylaxis and immunotherapy of experimental Pseudomonas aeruginosa sepsis].
    Author: Grishina IA, Terekhova RP, Marchuk AI.
    Journal: Zh Mikrobiol Epidemiol Immunobiol; 1986 Apr; (4):14-7. PubMed ID: 3087118.
    Abstract:
    The protective activity of pyoimmunogen II, lot 9, was studied on P. aeruginosa experimental sepsis used as a model. In experiments on rats the preparation was shown to be nontoxic according to the results of the determination of acute and chronic toxicity. The preparation under test produced a high protective effect in experiments on animals infected with various P. aeruginosa strains, irrespective of their virulence and immunotype. Anti-P. aeruginosa plasma, obtained by plasmapheresis from donors immunized with pyoimmunogen II, showed a curative effect when injected into experimental animals in a dose of 0.02 ml/g body weight at early stages of the infection.
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