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  • Title: In vitro model to compare the oxygen offloading behaviour of dodecafluoropentane emulsion (DDFPe).
    Author: Jayaraman MS, Graham K, Unger EC.
    Journal: Artif Cells Nanomed Biotechnol; 2019 Dec; 47(1):783-789. PubMed ID: 30873883.
    Abstract:
    The aim of this paper was to create an in vitro setup to quantify the oxygen offloading capabilities of dodecafluoropentane emulsion (DDFPe) in a hypoxic environment. Oxygen offloading from DDFPe was characterized under different gaseous environments and under pre-oxygenated conditions. Results of this study showed that (1) oxygen offloading is inversely related to the solubility of the selected sparging gas in saline and (2) both pre-oxygenated and simultaneously oxygenated DDFPe display similar magnitudes of oxygen transport. These results could be applicable to on-going and future studies involving a variety of hypoxic conditions where oxygen delivery might be therapeutically beneficial.
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