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  • Title: Pertussis toxin alters the growth characteristics of Swiss 3T3 cells.
    Author: Hildebrandt JD, Stolzenberg E, Graves J.
    Journal: FEBS Lett; 1986 Jul 14; 203(1):87-90. PubMed ID: 3087783.
    Abstract:
    Pertussis toxin (islet-activating protein) treatment of intact Swiss 3T3 cells causes a time- and dose-dependent loss of availability of a 40 kDa membrane protein for toxin-catalyzed ADP-ribosylation in subsequent incubations with [32P]NAD. In parallel, [3H]thymidine uptake by quiescent cells stimulated with fresh serum, cell doubling time and cell saturation density are all decreased 30-50%. These results cannot be accounted for by the potential effect of the toxin on cell cAMP levels. They suggest that a pertussis toxin substrate, probably Gi, modulates some component of growth regulation in Swiss 3T3 cells.
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