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  • Title: Elevated natural killer cytotoxicity in HLA-B8 and HLA-DR3-positive individuals.
    Author: Jakobisiak M, Saidman S, Schlaut J, Pazderka F, Dossetor JB.
    Journal: Immunol Lett; 1986 Mar; 12(2-3):61-3. PubMed ID: 3087867.
    Abstract:
    Increased natural killer cytotoxicity in persons positive for HLA-B8 and HLA-DR3 has been found. It is suggested that linkage disequilibrium between the genes coding for HLA-B8 and HLA-DR3 may have evolved as a result of strengthened immunological surveillance in individuals bearing them, as decrease in the frequency of both these antigens has recently been reported in patients with tumours.
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