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  • Title: Enantioselective Synthesis of C-N Axially Chiral N-Aryloxindoles by Asymmetric Rhodium-Catalyzed Dual C-H Activation.
    Author: Li H, Yan X, Zhang J, Guo W, Jiang J, Wang J.
    Journal: Angew Chem Int Ed Engl; 2019 May 13; 58(20):6732-6736. PubMed ID: 30893497.
    Abstract:
    The first enantioselective Satoh-Miura-type reaction is reported. A variety of C-N axially chiral N-aryloxindoles have been enantioselectively synthesized by an asymmetric rhodium-catalyzed dual C-H activation reaction of N-aryloxindoles and alkynes. High yields and enantioselectivities were obtained (up to 99 % yield and up to 99 % ee). To date, it is also the first example of the asymmetric synthesis of C-N axially chiral compounds by such a C-H activation strategy.
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