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  • Title: The utility of a single-point dosing protocol for predicting steady-state lithium levels.
    Author: Perry PJ, Alexander B, Prince RA, Dunner FJ.
    Journal: Br J Psychiatry; 1986 Apr; 148():401-5. PubMed ID: 3089352.
    Abstract:
    Two methods for predicting steady-state serum lithium level were compared prospectively in in-patients suffering from affective disorder. A single-point prospective administration model that required a single 24-hour serum lithium level, following a test dose produced statistically similar predictions of the observed steady-state lithium levels as did a model that required 12- and 36-hour levels. However, the latter two-point method produced significantly more accurate predictions from clinical interpretation. Although the two-point approach is preferable, the single-point method is clinically acceptable if its limitations of accuracy are taken into consideration.
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