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  • Title: Analysis of Genetic Polymorphism and Genetic Distance of 19 Autosomal STR Loci in Jiangsu Han Population.
    Author: Pan M, Gui H, Ju XB, Liu YT, Ye Q, Chen ZQ, Ding XJ, Chen Q, Zhou R, Gu M, Zhou HY.
    Journal: Fa Yi Xue Za Zhi; 2018 Jun; 34(6):650-655. PubMed ID: 30896106.
    Abstract:
    OBJECTIVES: To investigate the distribution of alleles in 19 autosomal short tandem repeat （STR） loci in Jiangsu Han population. METHODS: Goldeneye® 20A kit was used to detect 9 025 samples. Genetic analysis was performed on typing data of 19 autosomal STR loci, and genetic distance with other 17 populations was analyzed. RESULTS: All the 19 autosomal STR loci were consistent with the Hardy-Weinberg equilibrium （P>0.05）, with the heterozygosity 0.616 1-0.916 3, probability of match 0.012 8-0.202 6, discrimination power 0.797 4-0.987 2, probability of paternity exclusion 0.310 8-0.828 8, and polymorphic information content 0.561 7-0.913 6. The cumulative discrimination power and cumulative probability of exclusion were 0.999 999 999 999 999 998 434 1 and 0.999 999 989, respectively. The Jiangsu Han population had close genetic distances with the Han population in Tianjin, Hunan and Jilin, and significant difference with Han population in Aletai region in Xinjiang （P<0.05）. CONCLUSIONS: The STR allele polymorphism data and population genetic parameters of Jiangsu Han population can provide data support for the forensic application of these STR loci in Jiangsu Han population. 题目: 江苏汉族人群19个常染色体STR基因座基因多态性及遗传距离分析. 目的: 调查19个常染色体STR基因座在江苏汉族人群中的等位基因分布情况。. 方法: 采用Goldeneye® DNA身份鉴定系统20A对9 025例样本进行检测，对其中的19个常染色体STR基因座分型数据进行遗传学分析，并对其与其他17个地区人群间的遗传距离进行分析。. 结果: 19个常染色体STR基因座均符合Hardy-Weinberg平衡（P>0.05），杂合度为0.616 1~0.916 3，匹配概率为0.012 8~0.202 6，个体识别率为0.797 4~0.987 2，非父排除率为0.310 8~0.828 8，多态信息含量为0.561 7~0.913 6，累积个体识别率为0.999 999 999 999 999 998 434 1，累积非父排除率为0.999 999 989。江苏汉族人群与天津、湖南和吉林等汉族人群的遗传距离更近，与新疆阿勒泰汉族人群之间差异具有统计学意义（P<0.05）。. 结论: 获得较客观准确的江苏汉族人群STR基因座基因多态性数据和群体遗传学参数，可为上述STR基因座在江苏地区汉族人群的法医学应用提供数据支持。. 关键词: 法医遗传学；多态现象，遗传；短串联重复；遗传距离；汉族；江苏.
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