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  • Title: Natural killer activity in patients with acute viral hepatitis.
    Author: Chemello L, Mondelli M, Bortolotti F, Schiavon E, Pontisso P, Alberti A, Rondanelli EG, Realdi G.
    Journal: Clin Exp Immunol; 1986 Apr; 64(1):59-64. PubMed ID: 3089650.
    Abstract:
    Using the natural killer (NK) sensitive K562 cell line, enhanced NK cell cytotoxicity was demonstrable early in the course of acute hepatitis B while normal values were obtained in patients studied during convalescence. No evidence of enhanced NK activity was instead obtained in the course of acute non-A, non-B hepatitis. Serum levels of alpha-interferon, as determined by radioimmunoassay (RIA), were significantly increased in patients with acute hepatitis B showing enhanced NK cell activity but not in those with acute non-A, non-B hepatitis and normal NK cell activity. These results suggest that natural cytotoxicity may play a role early in the course of acute hepatitis type B, before antigen-specific T lymphocytes become fully operative.
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