These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Effects of aging on the in vitro release of gonadotropin-releasing hormone.
    Author: Jarjour LT, Handelsman DJ, Swerdloff RS.
    Journal: Endocrinology; 1986 Sep; 119(3):1113-7. PubMed ID: 3089764.
    Abstract:
    Secretion of GnRH from mediobasal hypothalami (MBH) of old (23 month) and young (2 month) male rats was studied in an in vitro superfusion system. GnRH efflux from both old and young MBH increased in response to stimulation with 20 microM norepinephrine and 40 microM naloxone; however, both basal and stimulated GnRH release were reduced from MBH of old rats despite similar hypothalamic GnRH content. The diminished basal secretion and responsiveness to two major stimuli of the GnRH neuron may be important in the well-known involution of the hypothalamic-pituitary testicular axis in aging male rats.
    [Abstract] [Full Text] [Related] [New Search]