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Title: [Association between plasma microRNA-29a and left ventricular hypertrophy in patients with hypertension].
Author: Yao SY, Liu J, Li Y, Wang M, Wang C, Xue H.
Journal: Zhonghua Xin Xue Guan Bing Za Zhi; 2019 Mar 24; 47(3):215-220. PubMed ID: 30897881.
Abstract:
Objective: Previous studies have shown that plasma microRNA-29a (miRNA-29a) is associated with myocardial fibrosis and the degree of cardiac hypertrophy in patients with hypertrophic cardiomyopathy. However, the relationship between plasma miRNA-29a and hypertensive left ventricular hypertrophy (LVH) has not yet been reported. So the purpose of this study is to investigate the relationship between the plasma miRNA-29a and hypertensive LVH. Method: Enrolled 168 hypertensive patients and classified the patients into 2 groups: those with LVH (LVH group, n=41) and those without LVH (NLVH group, n=127). All patients underwent echocardiography examination. Left ventricular mass index (LVMI) was calculated by interventricular septal thickness (IVSd), left ventricular posterior wall thickness(LVPWTd), left ventricular end diastolic dimension (LVEDD) and left ventricular mass index (LVMI) were obtained. Plasma levels of miRNA-29a were assessed by quantitative real-time polymerase chain reaction (qRT-PCR). The relationship between plasma miRNA-29a levels and LVH was analyzed. Results: Plasma miRNA-29a was significantly higher in LVH group than in NLVH group (0.52±0.10 vs. 0.37±0.07, t=9.788, P<0.01) . Pearson correlation analysis evidenced a positive correlation between plasma miRNA-29a levels and IVSd(R=0.459, P<0.01), LVPWTd (R=0.398, P<0.01), and LVMI (R=0.745, P<0.01). After adjustment for gender, age, systolic blood pressure, diastolic blood pressure, body mass index, hypertension duration, antihypertensive drugs, multiple regression analysis showed that there were still positive correlations between plasma miRNA-29a level and IVSd (β=0.535, P<0.01), LVPWTd (β=0.085, P<0.01), and LVMI (β=0.806, P<0.01). Conclusion: Plasma miRNA-29a level is positively associated with LVH in hypertensive patients, and future studies are warranted to explore if miRNA-29a could be used as a potential biomarker for LVH assessment in hypertensive patients. 目的： 探讨血浆微小RNA（miRNA）-29a与高血压左心室肥厚（LVH）的关系。 方法： 连续入选2016年12月至2017年11月在解放军总医院心内科门诊就诊的高血压患者168例，其中高血压伴LVH者41例，为高血压伴LVH组（简称为LVH组）；单纯性高血压者127例，为单纯性高血压组（简称为NLVH组）。收集入选者的一般临床资料，留取血样，以U6为内参照、采用实时定量PCR法测定入选者血浆中miRNA-29a的表达。入选者均行超声心动图检查获取相关参数，并计算左心室射血分数（LVEF）、左心室短轴缩短率（LVFS）、舒张期二尖瓣血流频谱左心室舒张早期最大血流与二尖瓣心房收缩期最大血流（E/A）比值、左心室质量（LVM）和左心室质量指数（LVMI）。采用Pearson相关分析分析miRNA-29a与LVH相关参数的关系。进一步采用多元线性回归分析分析miRNA-29a与LVH相关参数的关系，以血浆miRNA-29a表达为自变量，以舒张期左心室后壁厚度（LVPWTd）、室间隔厚度（IVSd）、舒张末期左心室内径（LVEDD）和收缩末期左心室内径（LVESD）、舒张末期左心室容积（LVEDV）和收缩末期左心室容积（LVESV）、左心房前后径（LAd）、右心房内径（RAd）、右心室内径（RVd）为应变量，并排除了传统的危险因素[包括性别、年龄、收缩压、舒张压、体重指数（BMI）、高血压病程、降压药物]等的影响。 结果： LVH组患者血浆miRNA-29a表达水平明显高于NLVH组（0.52±0.10比0.37±0.07，t=9.788，P<0.01）。Pearson相关分析结果显示，miRNA-29a与高血压患者LVMI（R=0.745，P<0.01）、IVSd（R=0.459，P<0.01）、LVPWTd（R=0.398，P<0.01）、LVEDD（R=0.345，P<0.01）、LVEDV（R=0.302，P<0.01）、LVESV（R=0.243，P<0.01）相关。排除了传统危险因素（性别、年龄、收缩压、舒张压、BMI、高血压病程、降压药物）的影响，多元线性回归分析结果进一步显示，miRNA-29a仍然与IVSd（β=0.535，P<0.01）、LVPWTd（β=0.085，P<0.01）、LVMI（β=0.806，P<0.01）、LVEDD（β=0.403，P<0.01）、LVESD（β=0.066，P<0.01）、LVEDV（β=0.374，P<0.01）、LVESV（β=0.293，P<0.01）相关。 结论： 血浆miRNA-29a表达水平与高血压LVH相关，其有可能成为高血压LVH新的分子标志物。.

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