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  • Title: [The suppressive effect of pyrrole-2-carboxylic acid on platelet aggregation].
    Author: Komiyama K, Tronquet C, Hirokawa Y, Funayama S, Satoh O, Umezawa I, Oishi S.
    Journal: Jpn J Antibiot; 1986 Mar; 39(3):746-50. PubMed ID: 3090299.
    Abstract:
    In the course of a search for novel antibiotics, an antiplatelet substance was isolated from the fermentation broth of Streptomyces sp. No. 82-85. Thereafter, the active substance was identified as pyrrole-2-carboxylic acid (P2C) by structural studies. The effects of P2C on adenosine diphosphate (ADP)-, arachidonic acid-, collagen- or tumor cell-induced platelet aggregation were examined in vitro and ex vivo. In in vitro studies, P2C (25-100 micrograms/ml) suppressed the aggregation of platelets of normal Wistar rats. The intraperitoneal administration of P2C (200 mg/kg) to rats and rabbits suppressed platelet aggregation induced by ADP, arachidonic acid and collagen when examined for 0.5-3 hours after administration. The agent also suppressed platelet aggregation induced by both mouse syngenic tumors, Meth-A fibrosarcoma and IMC carcinoma in vitro.
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