These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Prevention of neural myoinositol depletion in diabetic rats by aldose reductase inhibition with tolrestat.
    Author: Kemper C, Dvornik D.
    Journal: Proc Soc Exp Biol Med; 1986 Sep; 182(4):505-10. PubMed ID: 3090558.
    Abstract:
    The effect of the aldose reductase inhibitor tolrestat on the sugar and polyol contents in the sciatic nerve was investigated in male Wistar and Sprague-Dawley rats rendered diabetic with streptozocin. At a daily oral dose of 5 mg/kg, given for 10 days before and for 14 days after streptozocin injection, tolrestat completely prevented the accumulation of sorbitol and the depletion of myoinositol.
    [Abstract] [Full Text] [Related] [New Search]