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  • Title: Long-term effects of TRH administration on food intake and body weight in the rat.
    Author: Iglesias R, Llobera M, Montoya E.
    Journal: Pharmacol Biochem Behav; 1986 Jun; 24(6):1817-9. PubMed ID: 3090567.
    Abstract:
    The effect of long-term TRH administration through drinking water (0.2 mg/ml) on food and water intake and body weight has been studied in three groups of female rats: (1) thyroidectomized, (2) thyroidectomized receiving daily 250 micrograms/kg of L-T4, (3) sham-operated. Treatment with oral TRH for 30 days decreased body weight and increased food intake in sham-operated rats. No TRH effects on body weight or food consumption were observed in either of the other groups of thyroidectomized rats. TRH administration increased circulating T3 levels in sham-operated animals, but had no effects in either hypo- or hyperthyroid, thyroidectomized rats. It can be concluded that the TRH-induced increase on food intake is mediated through the pituitary-thyroid axis.
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