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  • Title: Two new alkaloids from the tubers of Corydalis ambigua subsp. amurensis and their anti-proliferative activity.
    Author: Liu Z, Mi Z, Wang P, Chang S, Han N, Yin J.
    Journal: Nat Prod Res; 2020 Dec; 34(23):3305-3312. PubMed ID: 30908089.
    Abstract:
    Two new alkaloids, including one benzophenanthridine type, dehydroambiguanine A (1) and one isoquinoline type, ambiguanine J (2) together with four (3-6) known alkaloids were isolated from the n-butanol fraction of Corydalis ambigua subsp. amurensis. Their structures were elucidated by comprehensive spectroscopic methods including HR-ESIMS and NMR, and the absolute configuration of compound 1 was further confirmed by the quantum ECD calculations. In addition, all isolated alkaloids (1-6) were determined their anti-proliferative effects of on A549 and HCT 116 cell by colorimetric MTT assay. Among them, Compounds 1 and 4 exhibited anti-proliferative activity on HCT 116 cell line with the IC50 value at 49.8 ± 4.79, and 89.2 ± 1.86 μM, respectively. Compounds 2 and 5 showed mild anti-proliferative activity against A549 cell with IC50 values at 60.2 ± 10.7, and 89.2 ± 12.9 μM, respectively. Their preliminary structure-activity relationship was also discussed.
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