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  • Title: Assessment of thrombogenicity of activated and non-activated prothrombin concentrates in a rat model.
    Author: Silberman S, Fareed J, Walenga J.
    Journal: Br J Exp Pathol; 1986 Aug; 67(4):597-604. PubMed ID: 3091059.
    Abstract:
    In vitro clotting activity of rats injected with different preparations of prothrombin concentrates was measured. Animals rendered deficient in vitamin K-dependent coagulation factors by early coumadin (warfarin) pretreatment, followed by injections of concentrate preparations were also evaluated. Findings indicate a dose-related response in abnormal coagulation changes demonstrable with each preparation and lack of protection of intravascular coagulation by coumadin anticoagulation. Furthermore, a role for in vivo factor VII activation of haemostasis following concentrate administration could not be elicited.
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