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  • Title: Using the 150 rule to prevent hepatotoxicity from acetaminophen.
    Author: Nicholas WA, Moore R.
    Journal: JAAPA; 2019 Apr; 32(4):51-53. PubMed ID: 30913151.
    Abstract:
    Acetaminophen-induced hepatotoxicity is the most common cause of acute liver failure in adults and a major cause of acute liver failure in children. Prompt treatment with N-acetylcysteine can mitigate hepatotoxicity and progression to liver failure. This article describes a 16-year-old girl who ingested a large dose of extra-strength acetaminophen, and how the 150 rule was used in her management.
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