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  • Title: The role of MAO in MPTP toxicity--a review.
    Author: Glover V, Gibb C, Sandler M.
    Journal: J Neural Transm Suppl; 1986; 20():65-76. PubMed ID: 3091762.
    Abstract:
    MPTP is oxidized to its toxic metabolite MPP+ by MAO B in both primate and rodent brains and this reaction can be inhibited by (-)-deprenyl. MPTP can also act as an inhibitor of both MAO A and B. There is some evidence that MAO B is localized predominantly in glia, and this would explain why dopamine uptake blockers also can prevent MPTP toxicity. The possibility that molecules with a similar action to MPTP cause idiopathic Parkinson's disease is discussed.
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