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  • Title: Co-existing of Neuromyelitis Optica and Fulminant Type 1 Diabetes.
    Author: Saheki T, Imachi H, Ibata T, Fukunaga K, Yoshioka Y, Kobayashi T, Sato S, Mizumoto K, Yoshimoto T, Lyu J, Dong T, Murao K.
    Journal: Intern Med; 2019 Jul 01; 58(13):1913-1916. PubMed ID: 30918186.
    Abstract:
    The patient was a 71-year-old woman with aquaporin-4-antibody positive neuromyelitis optica (NMO), with no history of diabetes. On admission, although she showed an extremely elevated plasma glucose level (1,080 mg/dL), her hemoglobin A1c level was low (7.1%), which indicated the rapid progression of diabetes. She also showed ketoacidosis and had a human leukocyte antigen haplotype, DRB1*09:01-DQB1*03:03 associated with Fulminant type 1 diabetes (FT1D). Based on these results, the patient was diagnosed with FT1D. We herein describe the first reported case of a patient with FT1D with NMO, which raises the possibility that T-cell-mediated autoimmunity is involved in the pathogenesis of both FT1D and NMO.
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