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  • Title: The Asymmetric A³(Aldehyde⁻Alkyne⁻Amine) Coupling: Highly Enantioselective Access to Propargylamines.
    Author: Mo JN, Su J, Zhao J.
    Journal: Molecules; 2019 Mar 28; 24(7):. PubMed ID: 30925732.
    Abstract:
    The recent developments in asymmetric A³ (aldehyde⁻alkyne⁻amine) coupling has been summarized in this review. Several interesting modifications of the ligands enabled the highly enantioselective synthesis of chiral propargylamines, which are further used in the construction of nitrogen-containing chiral building blocks.
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