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  • Title: Detection of HTLV-III/LAV antigens in peripheral blood lymphocytes from patients with AIDS.
    Author: Pekovic DD, Chausseau JP, Lapointe N, Michaud J, Garzon S, Strykowski H, Tsoukas C, Gilmore N, Goldman H, Gornitsky M.
    Journal: Arch Virol; 1986; 91(1-2):11-9. PubMed ID: 3092784.
    Abstract:
    HTLV-III was searched for in frozen sections of peripheral blood lymphocytes obtained from AIDS patients by an immunofluorescence technique. Human IgG against HTLV-III/LAV and monoclonal antibodies against HTLV-III/LAV P 24 antigen, yielded a strong cytoplasmic fluorescence in frozen sections of the lymphocytes. Some cells containing HTLV-III antigens displayed multinucleated giant forms. They also reacted with monoclonal antibodies against helper/inducer T-cells (OKT4+), as demonstrated by direct double staining immunofluorescence. Similarly, complexes of immunoglobulins and C3 component of complement were also detected on HTLV-III/LAV Ag expressing lymphocytes. Immunofluorescence study of frozen sections of peripheral blood lymphocytes appeared to be a simple, fast and reliable method for detection of HTLV-III/LAV Ag in AIDS patients.
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