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  • Title: Growth hormone-releasing hormone and clonidine stimulate biosynthesis of growth hormone in neonatal pituitaries.
    Author: Cozzi MG, Zanini A, Locatelli V, Cella SG, Müller EE.
    Journal: Biochem Biophys Res Commun; 1986 Aug 14; 138(3):1223-30. PubMed ID: 3092819.
    Abstract:
    Comparative studies were performed to verify the effect of growth hormone releasing hormone (GHRH) or clonidine (CLON), a compound thought to act via release of endogenous GHRH, in stimulating GH biosynthesis in the pituitary from neonatal and adult rats. In vitro preincubation for 1 h with GHRH (hpGRF-40, 10(-8) M) increased the incorporation of L-[3H]leucine in the electrophoretic band of GH in the pituitary from 10-day-old rats, but not in the gland from adult rats. Ex-vivo treatment with GHRH or CLON for 5 days was effective in stimulating GH biosynthesis only in the pituitary from neonatal rats. These data demonstrate that neonatal somatotropes are particularly sensitive to the GH-synthesizing activity of GHRH or a GHRH-releasing stimulus.
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