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  • Title: Brain temperature in the rat midbrain reticular formation is regulated by bombesin and TRH.
    Author: Mori M, Yamaguchi M, Yamada M, Kobayashi I, Kobayashi S, Ishikawa K, Suzuki M.
    Journal: Endocrinology; 1986 Oct; 119(4):1864-6. PubMed ID: 3093200.
    Abstract:
    We investigated the effects of intraventricular (ivt) injection of bombesin on the TRH-induced increase in temperature in the midbrain reticular formation (mrf) of the rat brain under pentobarbital anesthesia. Ivt injection of TRH in a dose of 3 nmol significantly antagonized the decrease in brain temperature induced by pentobarbital, and this antagonistic action of TRH was dose-related. Ivt injection of 3-300 pmol bombesin produced a dose-related decrease in brain temperature in response to 3 nmol TRH injection. The present data provide evidence that bombesin and TRH produce opposite actions on thermoregulation of the mrf in the rat.
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