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  • Title: Infantile Pyknocytosis: An Uncommon Cause of Newborn Hemolytic Anemia.
    Author: Castillo J, Ness TE, Mehta PS.
    Journal: J Pediatr Hematol Oncol; 2020 May; 42(4):e251-e253. PubMed ID: 30933020.
    Abstract:
    Infantile pyknocytosis is a rare cause of neonatal hemolytic anemia, which presents in the first few weeks of life. We report a classic case of infantile pyknocytosis that presented to our institution with rebound hyperbilirubinemia after receiving phototherapy. The infant was found to have a hemoglobin of 5.8 g/dL, requiring a total of 15 mL/kg of red blood cells (in 2 separate transfusions) before discharge. The diagnosis was ultimately made by a review of the peripheral blood smear. We review the literature and suggest pediatricians consider infantile pyknocytosis on their differential when hemolytic anemia presents in the newborn period.
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