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  • Title: Evidence for a Sertoli cell, FSH-suppressible inhibiting factor(s) of testicular steroidogenic activity.
    Author: Benahmed M, Morera AM, Chauvin MA.
    Journal: Biochem Biophys Res Commun; 1986 Aug 29; 139(1):169-78. PubMed ID: 3094507.
    Abstract:
    By using a model of immature porcine Leydig and Sertoli cells cultured in serum free defined medium, we evidenced a paracrine control of Leydig cell steroidogenic activity by Sertoli cells via a secreted inhibiting protein(s). This protein(s), partially purified using gel filtration (M.W. 20,000-30,000) suppresses the steroidogenic responsiveness to LH/hCG by decreasing the specific LH/hCG binding (52% decrease) and hormone steroid biosynthesis (73% decrease) at a level(s) located between cAMP production and pregnenolone formation. The suppression of this inhibitor(s) by FSH, in a dose dependent manner, is one mechanism by which FSH "sensitizes" Leydig cell response to LH/hCG stimulation.
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