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  • Title: Hyperpigmentation after Foamed Bleomycin Sclerotherapy for Vascular Malformations.
    Author: Milbar HC, Jeon H, Ward MA, Mitchell SE, Weiss CR, Cohen BA.
    Journal: J Vasc Interv Radiol; 2019 Sep; 30(9):1438-1442. PubMed ID: 30956080.
    Abstract:
    The present report documents 6 patients who developed distinctive hyperpigmented skin lesions after bleomycin sclerotherapy for vascular malformations of the face, neck, and extremities. The patients ranged in age from 2 to 65 years and included both black and white and male and female patients. The bleomycin treatment dose varied from 15 to 45 U, with 5 of the 6 patients receiving foamed bleomycin. The hyperpigmented lesions were near the patient's vascular anomaly and attributable to postprocedural cutaneous pressure (eg, electrocardiographic [ECG] leads or tape). Hyperpigmentation faded slowly over time but was visible up to 3 years after the procedure.
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