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  • Title: Near-Infrared Bioluminescence Imaging with a through-Bond Energy Transfer Cassette.
    Author: Abe M, Nishihara R, Ikeda Y, Nakajima T, Sato M, Iwasawa N, Nishiyama S, Paulmurugan R, Citterio D, Kim SB, Suzuki K.
    Journal: Chembiochem; 2019 Aug 01; 20(15):1919-1923. PubMed ID: 30957352.
    Abstract:
    A coelenterazine (CTZ) analogue emitting near-infrared (NIR) bioluminescence was synthesized for through-bond energy transfer (TBET)-based imaging modalities. The analogue, named Cy5-CTZ, was prepared by conjugating cyanine-5 (Cy5) dye to CTZ through an acetylene linker. This novel derivative is intrinsically fluorescent and emits NIR-shifted luminescence upon reacting with an appropriate luciferase, the Renilla luciferase. This Cy5-CTZ substrate is optically stable in physiological samples and rapidly permeabilize through the plasma membrane into the cytosolic compartment of live cells.
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