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  • Title: Development of Fibrates as Important Scaffolds in Medicinal Chemistry.
    Author: Giampietro L, Ammazzalorso A, Amoroso R, De Filippis B.
    Journal: ChemMedChem; 2019 Jun 05; 14(11):1051-1066. PubMed ID: 30957432.
    Abstract:
    Fibrates are a class of phenoxyisobutyric acid derivatives mainly used as anti-hyperlipidemic agents. The fibrate scaffold has undergone a variety of chemical modifications, providing a wide spectrum of biological activities. Within the last few years, the majority of new synthetic fibrate derivatives have demonstrated hypolipidemic activity through peroxisome proliferator-activated receptor α (PPARα) activation. However, some compounds containing the fibrate scaffold have shown different pharmacological properties, also independent of PPARα activation, such as anti-inflammatory, analgesic, antioxidant, and antiplatelet activities. The aim of this review is to highlight the structure-activity relationships (SAR) in evaluating the significance of fibrates in the field of medicinal chemistry.
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