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  • Title: Effects of cimetidine on jejunostomy effluents in patients with severe short-bowel syndrome.
    Author: Jacobsen O, Ladefoged K, Stage JG, Jarnum S.
    Journal: Scand J Gastroenterol; 1986 Sep; 21(7):824-8. PubMed ID: 3095911.
    Abstract:
    The effect of the H2-receptor blocking agent cimetidine on jejunal effluent was examined in eight short-bowel patients with high-output jejunostomies. Stool mass and faecal excretion of sodium and potassium were significantly reduced by intravenous injection of 400 mg cimetidine four times a day. The amount of calcium, magnesium, phosphate, zinc, and fat in jejunostomy effluent did not change significantly. Cimetidine may be considered an antidiarrhoeal drug in extensively small-bowel-resected patients with a jejunostomy and may reduce the need for parenteral saline supply in these patients.
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