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  • Title: Influence on platelet activity and red cell fluidity of epoprostenol and two stable prostacyclin analogues in vitro.
    Author: Maurin N.
    Journal: Arzneimittelforschung; 1986 Aug; 36(8):1180-3. PubMed ID: 3096342.
    Abstract:
    Not only epoprostenol (prostacyclin, PGI2) but also the two stable prostacyclin analogues CG 4203 (oxacyclic) and CG 4305 (carbacyclic) cause concentration dependent inhibition of thrombocyte function: pseudopod formation and aggregation after stimulation with ADP, collagen and arachidonic acid are inhibited to an extent dependent on dose. ADP-induced aggregation is inhibited 45% by 10 nmol/l epoprostenol 47% by 50 nmol/l CG 4203 and 25% by 50 nmol/l CG 4305. Epoprostenol itself improves red cell fluidity to an extent dependent on concentration, but the two analogues tested show no such effect.
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